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Jason Fung, M.D.: Fasting as a potent antidote to obesity, insulin resistance, type 2 diabetes, and the many symptoms of metabolic illness - Dr. Jason Fung
The Peter Attia Drive
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Jason Fung, M.D.: Fasting as a potent antidote to obesity, insulin resistance, type 2 diabetes, and the many symptoms of metabolic illness

The Peter Attia Drive

Peter Attia, Dr. Jason Fung

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If you ever look back and say 'Hey, where did we get this idea that we should eat six or eight times a day?' From nowhere. Somebody made it up, it stuck, and that was about it.

Time-Restricted Feeding & Fasting Have Higher Compliance Rates Than Dietary Restriction

I think the biggest benefit of time-restricted feeding is the psychological one ... People think intravenous access to food is essential for life. If they go more than two hours without a meal, the sky is gonna fall. So, in many ways, time-restricted feeding is just a way to prove to them that is total nonsense.

Dr. Jason Fung Treated a Diabetic Foot Ulcer With a Fasting Protocol

Testosterone is very anabolic to muscle, which insulin is as well, but testosterone is catabolic to fat, whereas insulin is anabolic to fat and anabolic to muscle. Cortisol, just to bring it full circle, is the worst of both worlds—hypercortisolemia is catabolic to muscle while anabolic to fat.

How Testosterone, Insulin, & Cortisol Affect Fat & Muscle

Hyperinsulinemia (too much insulin) is really what is behind abdominal obesity, high blood glucose, high blood pressure, low HDL, and hypertriglyceridemia. That's the metabolic syndrome.

Hyperinsulinemia Is the Main Driver of Metabolic Syndrome

We know that cortisol has a huge impact on body fatness ... If you get good sleep, you're more likely to be at a good weight. If you are sleep-deprived, for example, it's a stressful situation where cortisol is going to go up, then you're more likely to gain weight.

To a Certain Extent, Inflammation Causes Obesity

There's no more potent way to lower insulin than to fast.

Fasting Is the Best Way to Lower Insulin

You have three nutrients sensors: You have insulin, you have mTOR, and you have AMPK ... Insulin responds to dietary carbohydrates and dietary proteins. mTOR responds mostly to dietary proteins. AMPK actually measures the AMP to ATP ratio, so it actually doesn't care about what you eat; it just cares about the cellular energy availability.

Fasting Protects Against Diseases of Excessive Growth

Dr. Peter Attia recommend patients supplement with phosphatidylserine and GABA to aid sleep during a prolonged fast.

How Dr. Jason Fung Prepares First-Time Fasters for a Prolonged Fast

Fasting is what I call medical bariatrics. You get all the benefits of bariatric surgery without doing any surgery.

Fasting Is Medical Bariatrics — It Reverses Type 2 Diabetes

We see this all the time... As you prescribe insulin, people gain weight. You give sulfonylureas, which increase insulin, then people gain weight. You give them SGLT2s, which make insulin drop, then you lose weight.

Dr. Jason Fung Thinks Excess Insulin Causes Obesity

That, to me, is one of the big problems with insulin.... You're telling your body to grow all the time when it really shouldn't be growing all the time.

Excess Insulin Increases Cancer & Cardiovascular Disease Risk

I'm generally suspect of people who have very, very strong points of view on things in biology or medicine who no longer interact with patients.

Doctors Could Learn From the Way Physicists Conduct Experiments

Insulin has actually many, many different functions—only one of which is letting glucose into the cell.

The Paradox of Insulin Resistance: Why Giving a Diabetic More Insulin Isn't the Answer

Obesity itself is actually a protective mechanism against hyperinsulinemia and too much sugar.

Obesity & Insulin Resistance Are Protective Mechanisms Against Excess Insulin & Sugar

I think it's more likely that the hyperinsulinemia is driving the obesity rather than the other way around.

Dr. Jason Fung Thinks Excess Insulin Causes Obesity

In 2019, I think that there is no more promising agent than rapamycin for longevity.

Rapamycin Is the Most Promising Longevity Drug